George J Kontoghiorghes Selected Research

Deferiprone

6/2022	Deferiprone: A Forty-Year-Old Multi-Targeting Drug with Possible Activity against COVID-19 and Diseases of Similar Symptomatology.
12/2021	The need for a multi-level drug targeting strategy to curb the COVID-19 pandemic.
12/2020	Iron and Chelation in Biochemistry and Medicine: New Approaches to Controlling Iron Metabolism and Treating Related Diseases.
1/2020	The History of Deferiprone (L1) and the Paradigm of the Complete Treatment of Iron Overload in Thalassaemia.
7/2017	Prevention of Iron Overload and Long Term Maintenance of Normal Iron Stores in Thalassaemia Major Patients using Deferiprone or Deferiprone Deferoxamine Combination.
3/2016	New developments and controversies in iron metabolism and iron chelation therapy.
1/2016	Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with non-transfusion-dependent thalassemia syndromes.
11/2015	Phytochelators Intended for Clinical Use in Iron Overload, Other Diseases of Iron Imbalance and Free Radical Pathology.
3/2015	Characterization of the neuroprotective potential of derivatives of the iron chelating drug deferiprone.
12/2014	Transition of Thalassaemia and Friedreich ataxia from fatal to chronic diseases.

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George J Kontoghiorghes Research Topics

Disease

33	Iron Overload 06/2022 - 01/2003
21	Thalassemia 01/2020 - 01/2006
13	Neoplasms (Cancer) 01/2022 - 01/2006
9	beta-Thalassemia (Cooley's Anemia) 01/2016 - 01/2009
8	Iron Deficiencies 01/2021 - 01/2005
5	Chronic Disease (Chronic Diseases) 01/2020 - 01/2006
4	Friedreich Ataxia (Friedreich's Ataxia) 01/2020 - 01/2009
4	Hemochromatosis (Bronze Diabetes) 03/2016 - 01/2005
4	Heart Failure 12/2014 - 01/2008
4	Cardiomyopathies (Cardiomyopathy) 01/2014 - 01/2006
4	Agranulocytosis (Granulocytopenia) 07/2010 - 01/2003
3	COVID-19 06/2022 - 07/2021
3	Communicable Diseases (Infectious Diseases) 01/2020 - 05/2013
3	Infections 07/2017 - 01/2002
2	Kidney Diseases (Kidney Disease) 01/2014 - 01/2009
2	Sickle Cell Anemia (Hemoglobin S Disease) 09/2013 - 01/2011
2	Anemia 05/2013 - 01/2006
2	Renal Insufficiency (Renal Failure) 07/2010 - 05/2007
2	Heart Diseases (Heart Disease) 01/2006 - 11/2004
1	Pantothenate Kinase-Associated Neurodegeneration (Hallervorden-Spatz Disease) 01/2020
1	Splenomegaly 07/2017
1	Transfusion-Related Acute Lung Injury 01/2017
1	Central Nervous System Diseases (CNS Diseases) 03/2015
1	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2015
1	Alzheimer Disease (Alzheimer's Disease) 03/2015
1	Gastrointestinal Hemorrhage (Hematochezia) 07/2010
1	Exanthema (Rash) 07/2010
1	Alopecia (Baldness) 07/2010
1	Anaphylaxis (Anaphylactic Shock) 07/2010
1	Mucormycosis 06/2010
1	Cardiotoxicity 01/2008
1	Thrombosis (Thrombus) 01/2008
1	Liver Failure 01/2008
1	Thrombocytopenia (Thrombopenia) 05/2007
1	Cytopenia 05/2007
1	Siderosis 01/2006
1	Neutropenia 01/2003
1	Arthralgia (Joint Pain) 01/2003
1	Acquired Immunodeficiency Syndrome (AIDS) 01/2002

Drug/Important Bio-Agent (IBA)

42	IronIBA 06/2022 - 01/2002
36	DeferiproneIBA 06/2022 - 01/2002
25	Deferoxamine (Desferal)FDA LinkGeneric 12/2020 - 01/2003
10	Pharmaceutical PreparationsIBA 06/2022 - 01/2002
10	Chelating AgentsIBA 01/2022 - 01/2006
6	Deferasirox FDA Link 08/2021 - 05/2007
6	Free RadicalsIBA 12/2020 - 01/2008
6	Ferritins (Ferritin)IBA 01/2013 - 01/2006
3	AntioxidantsIBA 07/2020 - 03/2016
3	Proteins (Proteins, Gene)FDA Link 12/2014 - 01/2008
3	MetalsIBA 01/2013 - 01/2008
2	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2022 - 07/2020
2	XenobioticsIBA 12/2020 - 01/2013
2	maltolIBA 03/2016 - 11/2015
2	IonsIBA 01/2011 - 01/2008
2	CopperIBA 01/2011 - 01/2008
2	Transferrin (beta 2 Transferrin)IBA 01/2011 - 01/2006
2	Hydroxyurea (Hydrea)FDA LinkGeneric 01/2011 - 01/2008
2	ZincIBA 01/2008 - 01/2003
1	Ritonavir (Norvir)FDA Link 12/2021
1	remdesivirIBA 12/2021
1	Acetylcysteine (Siran)FDA LinkGeneric 12/2021
1	Drug CombinationsIBA 12/2021
1	molnupiravirIBA 12/2021
1	Dexamethasone (Maxidex)FDA LinkGeneric 12/2021
1	tocilizumab (atlizumab)FDA Link 12/2021
1	baricitinibIBA 12/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2020
1	HLA Antigens (Human Leukocyte Antigens)IBA 01/2017
1	AntibodiesIBA 01/2017
1	TropoloneIBA 11/2015
1	MimosineIBA 11/2015
1	FrataxinIBA 12/2014
1	Generic DrugsIBA 09/2013
1	Hemoglobins (Hemoglobin)IBA 05/2013
1	SiderophoresIBA 06/2010
1	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 01/2008
1	PlatinumIBA 01/2008
1	Mitoxantrone (Novantrone)FDA LinkGeneric 01/2008
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2008
1	DNA (Deoxyribonucleic Acid)IBA 01/2008
1	3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine)IBA 01/2008
1	4,4-difluororetinoic acidIBA 01/2008
1	Coordination ComplexesIBA 01/2008
1	Dexrazoxane (Zinecard)FDA LinkGeneric 01/2008
1	Dietary IronIBA 01/2005

Therapy/Procedure

15	Therapeutics 12/2021 - 01/2002
10	Chelation Therapy (Therapy, Chelation) 01/2016 - 01/2006
1	Drug Therapy (Chemotherapy) 06/2022
1	Erythrocyte Transfusion 01/2017
1	Complementary Therapies (Alternative Medicine) 01/2014
1	Splenectomy 01/2013
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2009
1	Vascular Access Devices (Arterial Line) 01/2008